News & Highlights
Congratulations to Dr. Sophie Brouard who co-leads Team IV “Immunoregulation and Immunointervention in Transplantation and Autoimmunity” of the Center for Research in Transplantation and Immunology (CRTI-UMR 1064) and partner of LUNG innOvatiOn for receiving the CNRS 2020 Innovation Medal.
Trained as a veterinarian, Sophie Brouard gradually became interested in the issue of transplant rejection in kidney and lung transplantation. Now CNRS Research Director at the Center for Research in Transplantation and Immunology (CRTI, University of Nantes/Inserm/ITUN/CHU of Nantes), she works on the reduction of treatments that avoid rejection but cause many side effects. “With my medical and veterinary training, I always needed to know what applications my research could be used for,” she explains. Originally, by studying a few rare kidney transplant patients who could manage without treatment, she discovered the regulation of B lymphocytes and investigated their mechanisms of action with a view to possible therapy. Part of her research is also focused on identifying biomarkers to evaluate, predict and diagnose the risk of kidney and lung transplant rejection in order to better anticipate it and adapt treatments. As a fine expert in the needs of industry and the valorisation actors, she is able to use her research to meet the needs of the business sector. With 163 scientific publications and 13 patents, it is essential for her to remember that “research is teamwork”. In partnership with a few academic colleagues, she founded two companies: TcLand Expression and Effimune, now OSE Immunotherapeutics, which develops therapeutic tools in the various fields of cancer and autoimmune diseases.