{"id":980,"date":"2020-06-19T11:00:02","date_gmt":"2020-06-19T09:00:02","guid":{"rendered":"https:\/\/lungo2.fr\/pneumocystis-after-lung-transplantation-a-multi-center-retrospective-study\/"},"modified":"2021-01-18T15:51:53","modified_gmt":"2021-01-18T14:51:53","slug":"pneumocystis-after-lung-transplantation-a-multi-center-retrospective-study","status":"publish","type":"post","link":"https:\/\/lungo2.fr\/en\/pneumocystis-after-lung-transplantation-a-multi-center-retrospective-study\/","title":{"rendered":"Pneumocystis after lung transplantation: A multi-center retrospective study"},"content":{"rendered":"<p><em>Pneumocystis jirovecii<\/em> is a fungus responsible for potentially lethal opportunistic acute pulmonary infections in immune-depressed patients, particularly through solid organ transplantation. Current data in the literature are poor in the subpopulation of lung transplant patients.<\/p>\n<p>We have designed a retrospective multi-center study in 9 lung transplant centers in France to include 47 patients who developed pneumocystis after transplantation between January 2010 and October 2017. The etiologies of the transplants were diverse.<\/p>\n<p>The minimum incidence was estimated at 2.7\/1000 patients\/year. Only 64% of the patients were on prophylaxis prior to the episode. The delay between infection and transplantation ranged from 7 days to 25 years, arguing for early and lifelong drug prophylaxis. All patients were on several immunosuppressive drugs including corticosteroids. In 91% of cases, microbiological diagnosis was made by PCR in bronchoalveolar lavage. Co-infections were frequent (67%), mainly respiratory.<\/p>\n<p>More than half of the cases were hospitalized in intensive care. Mortality was 23% at D+90. The curative treatment was trimethoprim-sulfamethoxazole in 78% of cases. The management of corticosteroid therapy during the episode was variable, with no significant association with prognosis. Mortality was associated with <em>Aspergillus<\/em> coinfection or <em>Pseudomonas aeruginosa<\/em>, a lower FEV1 and everolimus immunosuppression. There were no functional respiratory sequelae at 1 year in the survivors.<\/p>\n<p><em><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0954611120301591?via%3Dihub\" target=\"_blank\" rel=\"noopener\"><u>Delbove et al.<\/u> Pneumocystis pneumonia after lung transplantation: A retrospective multicenter study. Respiratory Medicine, 2020, 106019, ISSN 0954-6111, https:\/\/doi.org\/10.1016\/j.rmed.2020.106019<\/a>,\u00a0<\/em><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pneumocystis jirovecii is a fungus responsible for potentially lethal opportunistic acute pulmonary infections in immune-depressed patients, particularly through solid organ transplantation. Current data in the literature are&#8230; <br \/><a class=\"readmore\" href=\"https:\/\/lungo2.fr\/en\/pneumocystis-after-lung-transplantation-a-multi-center-retrospective-study\/\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":982,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15],"tags":[],"class_list":["post-980","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publication"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Pneumocystis after lung transplantation: A multi-center retrospective study - LungO2<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lungo2.fr\/en\/pneumocystis-after-lung-transplantation-a-multi-center-retrospective-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pneumocystis after lung transplantation: A multi-center retrospective study - LungO2\" \/>\n<meta property=\"og:description\" content=\"Pneumocystis jirovecii is a fungus responsible for potentially lethal opportunistic acute pulmonary infections in immune-depressed patients, particularly through solid organ transplantation. 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